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Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights

Initially regarded as “epigenetic modifiers” acting predominantly through chromatin remodeling via histone acetylation, HDACIs, alternatively referred to as lysine deacetylase or simply deacetylase inhibitors, have since been recognized to exert multiple cytotoxic actions in cancer cells, often thro...

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Bibliografiske detaljer
Main Authors: Bose, Prithviraj, Dai, Yun, Grant, Steven
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117710/
https://ncbi.nlm.nih.gov/pubmed/24769080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.04.004
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