A new opioid designed multiple ligand derived from the μ opioid agonist endomorphin-2 and the δ opioid antagonist pharmacophore Dmt-Tic

Opioid compounds with mixed μ agonist / δ antagonist properties could be used as analgesics with low propensity to induce tolerance and dependence. Here we report the synthesis of a new designed multiple ligand deriving from the μ selective agonist endomorphin-2 and the δ selective antagonist pharma...

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Detalhes bibliográficos
Main Authors: Salvadori, Severo, Trapella, Claudio, Fiorini, Stella, Negri, Lucia, Lattanzi, Roberta, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Balboni, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084217/
https://ncbi.nlm.nih.gov/pubmed/17851080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.08.047
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