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Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell- and Toll-like receptors.
Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM) and somatic hyperconversion. In general high levels of AID expression are found in mature B cells responding to antigens. However, AID expression and SHM...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2082107/ https://ncbi.nlm.nih.gov/pubmed/17658280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.05.018 |
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