Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases

In eukaryotes, shortening of the 3′-poly(A) tail is the rate-limiting step in the degradation of most mRNAs, and two major mRNA deadenylase complexes—Caf1–Ccr4 and Pan2–Pan3—play central roles in this process, referred to as deadenylation. However, the molecular mechanism triggering deadenylation re...

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Bibliografiske detaljer
Main Authors: Funakoshi, Yuji, Doi, Yusuke, Hosoda, Nao, Uchida, Naoyuki, Osawa, Masanori, Shimada, Ichio, Tsujimoto, Masafumi, Suzuki, Tsutomu, Katada, Toshiaki, Hoshino, Shin-ichi
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2007
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2081979/
https://ncbi.nlm.nih.gov/pubmed/18056425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1597707
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