Quantitative Characterization of Tob Interactions Provides the Thermodynamic Basis for Translation Termination-coupled Deadenylase Regulation

Translation termination-coupled deadenylation is the first and often the rate-limiting step of eukaryotic mRNA decay in which two deadenylases, Ccr4-Caf1 and Pan2, play key roles. One of the deadenylases, Caf1, associates with Tob, which recruits Caf1 to the poly(A) tail through interactions with a...

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Detalhes bibliográficos
Main Authors: Ruan, Lin, Osawa, Masanori, Hosoda, Nao, Imai, Shunsuke, Machiyama, Asako, Katada, Toshiaki, Hoshino, Shin-ichi, Shimada, Ichio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934630/
https://ncbi.nlm.nih.gov/pubmed/20595394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.138867
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