Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin.

We have developed chimeric Fab fragments of MAb A7 (chA7Fab) and have reported on their potential usefulness as a carrier of neocarzinostatin (NCS). However, a large amount of chA7Fab accumulates in the kidneys which might cause renal failure. This was one of the major side-effects of the chA7Fab-NC...

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Bibliografski detalji
Glavni autori: Otsuji, E., Yamaguchi, T., Matsumura, H., Yamamoto, K., Tsuruta, H., Yata, Y., Nishi, H., Okamoto, K., Kitamura, K., Takahashi, T.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1996
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074675/
https://ncbi.nlm.nih.gov/pubmed/8761376
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