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In vivo Efficacy of Neocarzinostatin Coupled with Fab Human/Mouse Chimeric Monoclonal Antibody A7 against Human Colorectal Cancer

The anticancer polypeptide neocarzinostatin (NCS) was covalently coupled to a human/mouse chimeric Fab A7 monoclonal antibody (chFabA7) and the in vivo efficacy of this conjugate was examined. NCS concentration assay was carried out, and acute toxicity and tumoricidal effects were examined. The conc...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Yamaguchi, Toshiharu, Tsurumi, Hiroshi, Kotani, Tatsuya, Yamaoka, Nobuki, Otsuji, Eigo, Kitamura, Kazuya, Takahashi, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919422/
https://ncbi.nlm.nih.gov/pubmed/8144398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1994.tb02078.x
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