In vivo Efficacy of Neocarzinostatin Coupled with Fab Human/Mouse Chimeric Monoclonal Antibody A7 against Human Colorectal Cancer

The anticancer polypeptide neocarzinostatin (NCS) was covalently coupled to a human/mouse chimeric Fab A7 monoclonal antibody (chFabA7) and the in vivo efficacy of this conjugate was examined. NCS concentration assay was carried out, and acute toxicity and tumoricidal effects were examined. The conc...

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Bibliografiske detaljer
Udgivet i:Jpn J Cancer Res
Main Authors: Yamaguchi, Toshiharu, Tsurumi, Hiroshi, Kotani, Tatsuya, Yamaoka, Nobuki, Otsuji, Eigo, Kitamura, Kazuya, Takahashi, Toshio
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 1994
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919422/
https://ncbi.nlm.nih.gov/pubmed/8144398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1994.tb02078.x
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