In vivo Efficacy of Neocarzinostatin Coupled with Fab Human/Mouse Chimeric Monoclonal Antibody A7 against Human Colorectal Cancer

The anticancer polypeptide neocarzinostatin (NCS) was covalently coupled to a human/mouse chimeric Fab A7 monoclonal antibody (chFabA7) and the in vivo efficacy of this conjugate was examined. NCS concentration assay was carried out, and acute toxicity and tumoricidal effects were examined. The conc...

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Vydáno v:Jpn J Cancer Res
Hlavní autoři: Yamaguchi, Toshiharu, Tsurumi, Hiroshi, Kotani, Tatsuya, Yamaoka, Nobuki, Otsuji, Eigo, Kitamura, Kazuya, Takahashi, Toshio
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 1994
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919422/
https://ncbi.nlm.nih.gov/pubmed/8144398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1994.tb02078.x
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