Biodistribution of Neocarzinostatin Conjugated to Chimeric Fab Fragments of the Monoclonal Antibody A7 in Nude Mice Bearing Human Pancreatic Cancer Xenografts

In this study, we conjugated chimeric Fab fragments of the monoclonal antibody (MAb) A7, which reacts with pancreatic cancers, to the antitumor drug neocarzinostatin (chA7Fab‐NCS) and intravenously injected (125)I‐labeled chA7Fab‐NCS into nude mice bearing a human pancreatic cancer xenograft. We com...

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Bibliographic Details
Published in:Jpn J Cancer Res
Main Authors: Otsuji, Eigo, Yamaguchi, Toshiharu, Yamaoka, Nobuki, Taniguchi, Katsunori, Kato, Makoto, Kotani, Tatsuya, Kitamura, Kazuya, Takahashi, Toshio
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 1994
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919492/
https://ncbi.nlm.nih.gov/pubmed/8014111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1994.tb02391.x
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