The major human and mouse granzymes are structurally and functionally divergent

Approximately 2% of mammalian genes encode proteases. Comparative genomics reveals that those involved in immunity and reproduction show the most interspecies diversity and evidence of positive selection during evolution. This is particularly true of granzymes, the cytotoxic proteases of natural kil...

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Bibliographic Details
Main Authors: Kaiserman, Dion, Bird, Catherina H., Sun, Jiuru, Matthews, Antony, Ung, Kheng, Whisstock, James C., Thompson, Philip E., Trapani, Joseph A., Bird, Phillip I.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2006
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064598/
https://ncbi.nlm.nih.gov/pubmed/17116752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200606073
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