A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection

Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susce...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Andoniou, Christopher E., Sutton, Vivien R., Wikstrom, Matthew E., Fleming, Peter, Thia, Kevin Y. T., Matthews, Antony Y., Kaiserman, Dion, Schuster, Iona S., Coudert, Jerome D., Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I., Trapani, Joseph A., Degli-Esposti, Mariapia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263754/
https://ncbi.nlm.nih.gov/pubmed/25502180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004526
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