A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection

Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susce...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Pathog
Prif Awduron: Andoniou, Christopher E., Sutton, Vivien R., Wikstrom, Matthew E., Fleming, Peter, Thia, Kevin Y. T., Matthews, Antony Y., Kaiserman, Dion, Schuster, Iona S., Coudert, Jerome D., Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I., Trapani, Joseph A., Degli-Esposti, Mariapia A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263754/
https://ncbi.nlm.nih.gov/pubmed/25502180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004526
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