A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection

Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susce...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Andoniou, Christopher E., Sutton, Vivien R., Wikstrom, Matthew E., Fleming, Peter, Thia, Kevin Y. T., Matthews, Antony Y., Kaiserman, Dion, Schuster, Iona S., Coudert, Jerome D., Eldi, Preethi, Chaudhri, Geeta, Karupiah, Gunasegaran, Bird, Phillip I., Trapani, Joseph A., Degli-Esposti, Mariapia A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263754/
https://ncbi.nlm.nih.gov/pubmed/25502180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004526
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