Selective Regulation of Apoptosis: the Cytotoxic Lymphocyte Serpin Proteinase Inhibitor 9 Protects against Granzyme B-Mediated Apoptosis without Perturbing the Fas Cell Death Pathway

Cytotoxic lymphocytes (CLs) induce caspase activation and apoptosis of target cells either through Fas activation or through release of granule cytotoxins, particularly granzyme B. CLs themselves resist granule-mediated apoptosis but are eventually cleared via Fas-mediated apoptosis. Here we show th...

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Bibliographic Details
Main Authors: Bird, Catherina H., Sutton, Vivien R., Sun, Jiuru, Hirst, Claire E., Novak, Andrea, Kumar, Sharad, Trapani, Joseph A., Bird, Phillip I.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC109224/
https://ncbi.nlm.nih.gov/pubmed/9774654
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