Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

Cytotoxic T lymphocyte (CTL)–induced death triggered by the granule exocytosis pathway involves the perforin-dependent delivery of granzymes to the target cell. Gene targeting has shown that perforin is essential for this process; however, CTL deficient in the key granzymes A and B maintain the abil...

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Main Authors: Waterhouse, Nigel J., Sutton, Vivien R., Sedelies, Karin A, Ciccone, Annette, Jenkins, Misty, Turner, Stephen J., Bird, Phillip I., Trapani, Joseph A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2006
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063797/
https://ncbi.nlm.nih.gov/pubmed/16606695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200510072
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