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Expression of High Levels of Human Proteinase Inhibitor 9 Blocks Both Perforin/Granzyme and Fas/Fas Ligand-mediated Cytotoxicity

Proteinase inhibitor 9 (PI-9, SerpinB9) is the only known human intracellular granzyme B inhibitor. Whether expression of PI-9 is sufficient to block cytolysis induced by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells remains controversial. To evaluate the roles of PI-9, we isolated an...

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Main Authors: Cunningham, Thomas D., Jiang, Xinguo, Shapiro, David J.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655900/
https://ncbi.nlm.nih.gov/pubmed/17490628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2007.03.004
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