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Structure of granzyme C reveals an unusual mechanism of protease autoinhibition
Proteases act in important homeostatic pathways and are tightly regulated. Here, we report an unusual structural mechanism of regulation observed by the 2.5-Å X-ray crystal structure of the serine protease, granzyme C. Although the active-site triad residues adopt canonical conformations, the oxyani...
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| Главные авторы: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666993/ https://ncbi.nlm.nih.gov/pubmed/19299505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811968106 |
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