Conservation of the Extended Substrate Specificity Profiles Among Homologous Granzymes Across Species

Granzymes are structurally related serine proteases involved in cell death and immunity. To date four out of five human granzymes have assigned orthologs in mice; however for granzyme H, no murine ortholog has been suggested and its role in cytotoxicity remains controversial. Here, we demonstrate th...

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Detalhes bibliográficos
Main Authors: Plasman, Kim, Maurer-Stroh, Sebastian, Ahmad, Jamshaid, Hao, Han, Kaiserman, Dion, Sirota, Fernanda L., Jonckheere, Veronique, Bird, Phillip I., Gevaert, Kris, Van Damme, Petra
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790301/
https://ncbi.nlm.nih.gov/pubmed/23788529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.028670
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