Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

The Bcl-2 family regulates apoptosis by controlling mitochondrial integrity. To clarify whether its prosurvival members function by sequestering their Bcl-2 homology 3 (BH3)–only ligands or their multidomain relatives Bak and Bax, we analyzed whether four prosurvival proteins differing in their abil...

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Bibliografiske detaljer
Main Authors: Uren, Rachel T., Dewson, Grant, Chen, Lin, Coyne, Stephanie C., Huang, David C.S., Adams, Jerry M., Kluck, Ruth M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2007
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064136/
https://ncbi.nlm.nih.gov/pubmed/17452531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200606065
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