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M line–deficient titin causes cardiac lethality through impaired maturation of the sarcomere
Titin, the largest protein known to date, has been linked to sarcomere assembly and function through its elastic adaptor and signaling domains. Titin's M-line region contains a unique kinase domain that has been proposed to regulate sarcomere assembly via its substrate titin cap (T-cap). In thi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063865/ https://ncbi.nlm.nih.gov/pubmed/16702235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200601014 |
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