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M line–deficient titin causes cardiac lethality through impaired maturation of the sarcomere

Titin, the largest protein known to date, has been linked to sarcomere assembly and function through its elastic adaptor and signaling domains. Titin's M-line region contains a unique kinase domain that has been proposed to regulate sarcomere assembly via its substrate titin cap (T-cap). In thi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Weinert, Stefanie, Bergmann, Nora, Luo, Xiuju, Erdmann, Bettina, Gotthardt, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063865/
https://ncbi.nlm.nih.gov/pubmed/16702235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200601014
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