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M line–deficient titin causes cardiac lethality through impaired maturation of the sarcomere

Titin, the largest protein known to date, has been linked to sarcomere assembly and function through its elastic adaptor and signaling domains. Titin's M-line region contains a unique kinase domain that has been proposed to regulate sarcomere assembly via its substrate titin cap (T-cap). In thi...

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Bibliografske podrobnosti
Main Authors: Weinert, Stefanie, Bergmann, Nora, Luo, Xiuju, Erdmann, Bettina, Gotthardt, Michael
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063865/
https://ncbi.nlm.nih.gov/pubmed/16702235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200601014
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