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Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations

The passive stiffness of cardiac muscle plays a critical role in ventricular filling during diastole and is determined by the extracellular matrix and the sarcomeric protein titin. Titin spans from the Z-disk to the M-band of the sarcomere and also contains a large extensible region that acts as a m...

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Detalhes bibliográficos
Main Authors: Anderson, Brian R., Granzier, Henk L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484226/
https://ncbi.nlm.nih.gov/pubmed/22910434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2012.08.003
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