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RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol

Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice aga...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Smallshaw, Joan E., Richardson, James A., Vitetta, Ellen S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049008/
https://ncbi.nlm.nih.gov/pubmed/17875350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2007.08.018
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