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3′-O-modified nucleotides as reversible terminators for pyrosequencing
Pyrosequencing is a method used to sequence DNA by detecting the pyrophosphate (PPi) group that is generated when a nucleotide is incorporated into the growing DNA strand in polymerase reaction. However, this method has an inherent difficulty in accurately deciphering the homopolymeric regions of th...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2034218/ https://ncbi.nlm.nih.gov/pubmed/17923668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707495104 |
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