Four-color DNA sequencing with 3′-O-modified nucleotide reversible terminators and chemically cleavable fluorescent dideoxynucleotides

DNA sequencing by synthesis (SBS) on a solid surface during polymerase reaction can decipher many sequences in parallel. We report here a DNA sequencing method that is a hybrid between the Sanger dideoxynucleotide terminating reaction and SBS. In this approach, four nucleotides, modified as reversib...

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Detalhes bibliográficos
Main Authors: Guo, Jia, Xu, Ning, Li, Zengmin, Zhang, Shenglong, Wu, Jian, Kim, Dae Hyun, Sano Marma, Mong, Meng, Qinglin, Cao, Huanyan, Li, Xiaoxu, Shi, Shundi, Yu, Lin, Kalachikov, Sergey, Russo, James J., Turro, Nicholas J., Ju, Jingyue
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442126/
https://ncbi.nlm.nih.gov/pubmed/18591653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804023105
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