3′-O-modified nucleotides as reversible terminators for pyrosequencing

Pyrosequencing is a method used to sequence DNA by detecting the pyrophosphate (PPi) group that is generated when a nucleotide is incorporated into the growing DNA strand in polymerase reaction. However, this method has an inherent difficulty in accurately deciphering the homopolymeric regions of th...

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Bibliografiske detaljer
Main Authors:	Wu, Jian, Zhang, Shenglong, Meng, Qinglin, Cao, Huanyan, Li, Zengmin, Li, Xiaoxu, Shi, Shundi, Kim, Dae Hyun, Bi, Lanrong, Turro, Nicholas J., Ju, Jingyue
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2007
Fag:	Physical Sciences
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2034218/ https://ncbi.nlm.nih.gov/pubmed/17923668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707495104
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3′-O-modified nucleotides as reversible terminators for pyrosequencing

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