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How evolution makes proteins fold quickly

Sequences of fast-folding model proteins (48 residues long on a cubic lattice) were generated by an evolution-like selection toward fast folding. We find that fast-folding proteins exhibit a specific folding mechanism in which all transition state conformations share a smaller subset of common conta...

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Detalhes bibliográficos
Main Authors: Mirny, Leonid A., Abkevich, Victor I., Shakhnovich, Eugene I.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20198/
https://ncbi.nlm.nih.gov/pubmed/9560213
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