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Simulation, experiment, and evolution: Understanding nucleation in protein S6 folding

In this study, we explore nucleation and the transition state ensemble of the ribosomal protein S6 using a Monte Carlo (MC) Go model in conjunction with restraints from experiment. The results are analyzed in the context of extensive experimental and evolutionary data. The roles of individual residu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hubner, Isaac A., Oliveberg, Mikael, Shakhnovich, Eugene I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC420398/
https://ncbi.nlm.nih.gov/pubmed/15150413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401672101
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