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Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways

Push–pull networks are ubiquitous in signal transduction pathways in both prokaryotic and eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order ultrasensitivity. In a push–pull network, two antagonistic enzymes control the activity of a protein by covalent mo...

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Autors principals: van Albada, Siebe B, ten Wolde, Pieter Rein
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014792/
https://ncbi.nlm.nih.gov/pubmed/17937496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030195
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