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Enzyme Localization Can Drastically Affect Signal Amplification in Signal Transduction Pathways

Push–pull networks are ubiquitous in signal transduction pathways in both prokaryotic and eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order ultrasensitivity. In a push–pull network, two antagonistic enzymes control the activity of a protein by covalent mo...

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Detalhes bibliográficos
Main Authors: van Albada, Siebe B, ten Wolde, Pieter Rein
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014792/
https://ncbi.nlm.nih.gov/pubmed/17937496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030195
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