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Interim analyses and sequential designs in phase III studies

Recruitment of patients to a clinical trial usually occurs over a period of time, resulting in the steady accumulation of data throughout the trial's duration. Yet, according to traditional statistical methods, the sample size of the trial should be determined in advance, and data collected on...

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Detalhes bibliográficos
Main Authors: Todd, Susan, Whitehead, Anne, Stallard, Nigel, Whitehead, John
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014474/
https://ncbi.nlm.nih.gov/pubmed/11421995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01382.x
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