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Bayesian group sequential designs for phase III emergency medicine trials: a case study using the PARAMEDIC2 trial
BACKGROUND: Phase III trials often require large sample sizes, leading to high costs and delays in clinical decision-making. Group sequential designs can improve trial efficiency by allowing for early stopping for efficacy and/or futility and thus may decrease the sample size, trial duration and ass...
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| Izdano u: | Trials |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6961266/ https://ncbi.nlm.nih.gov/pubmed/31937351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-019-4024-x |
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