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Bayesian group sequential designs for phase III emergency medicine trials: a case study using the PARAMEDIC2 trial

BACKGROUND: Phase III trials often require large sample sizes, leading to high costs and delays in clinical decision-making. Group sequential designs can improve trial efficiency by allowing for early stopping for efficacy and/or futility and thus may decrease the sample size, trial duration and ass...

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Pubblicato in:Trials
Autori principali: Ryan, Elizabeth G., Stallard, Nigel, Lall, Ranjit, Ji, Chen, Perkins, Gavin D., Gates, Simon
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961266/
https://ncbi.nlm.nih.gov/pubmed/31937351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-019-4024-x
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