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Learning from previous responses in phase I dose-escalation studies

Dose escalation in phase I studies is generally performed on the basis of clinical experience and judgement. In this paper some of the statistical approaches that have been proposed for the formalization of the procedure are described. Apart from the use of the Continual Reassessment Method in oncol...

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Detalhes bibliográficos
Main Authors: Whitehead, John, Zhou, Yinghui, Stallard, Nigel, Todd, Susan, Whitehead, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014510/
https://ncbi.nlm.nih.gov/pubmed/11453884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01383.x
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