Interim analyses and sequential designs in phase III studies

Recruitment of patients to a clinical trial usually occurs over a period of time, resulting in the steady accumulation of data throughout the trial's duration. Yet, according to traditional statistical methods, the sample size of the trial should be determined in advance, and data collected on...

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Bibliographic Details
Main Authors: Todd, Susan, Whitehead, Anne, Stallard, Nigel, Whitehead, John
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
Subjects:
Review Series
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014474/
https://ncbi.nlm.nih.gov/pubmed/11421995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01382.x
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