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Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase
AIMS: To investigate the rate of excretion and routes of metabolism of tolcapone, a novel inhibitor of catechol-O-methyltransferase (COMT). METHODS: Six healthy male volunteers were given 200 mg [(14)C]-tolcapone (approximately 50 μCi) orally. To assess excretion balance and to identify metabolites,...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014389/ https://ncbi.nlm.nih.gov/pubmed/10583021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00036.x |
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