Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase

AIMS: To investigate the rate of excretion and routes of metabolism of tolcapone, a novel inhibitor of catechol-O-methyltransferase (COMT). METHODS: Six healthy male volunteers were given 200 mg [(14)C]-tolcapone (approximately 50 μCi) orally. To assess excretion balance and to identify metabolites,...

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Bibliographic Details
Main Authors: Jorga, Karin, Fotteler, Bärbel, Heizmann, Peter, Gasser, Rodolfo
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1999
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014389/
https://ncbi.nlm.nih.gov/pubmed/10583021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00036.x
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