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The catechol-O-methyltransferase inhibitor, tolcapone, increases the bioavailability of unmethylated (−)-epigallocatechin-3-gallate in mice()

(−)-Epigallocatechin-3-gallate (EGCG), has been shown to inhibit cancer in vivo. EGCG, however, is rapidly methylated by catechol-O-methyl transferase (COMT), which reduces its cancer preventive efficacy. Tolcapone (TOL), is a clinically-used COMT inhibitor. Here, we examined the effect of TOL on th...

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Detalhes bibliográficos
Publicado no:J Funct Foods
Main Authors: Forester, Sarah C., Lambert, Joshua D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509505/
https://ncbi.nlm.nih.gov/pubmed/26213577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jff.2015.05.012
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