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Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats
OBJECTIVE(S): Dopamine plays an important role in cognitive functions. Inhibition of the dopamine-degrading enzyme catechol-O-methyltransferase (COMT) may have beneficial effects. Our aim was to assess the effect of COMT inhibitor tolcapone (TCP) on learning and memory in naïve and haloperidol-chall...
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| Опубликовано в: : | Iran J Basic Med Sci |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Mashhad University of Medical Sciences
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6570742/ https://ncbi.nlm.nih.gov/pubmed/31231499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2019.33025.7890 |
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