Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats

OBJECTIVE(S): Dopamine plays an important role in cognitive functions. Inhibition of the dopamine-degrading enzyme catechol-O-methyltransferase (COMT) may have beneficial effects. Our aim was to assess the effect of COMT inhibitor tolcapone (TCP) on learning and memory in naïve and haloperidol-chall...

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Vydáno v:Iran J Basic Med Sci
Hlavní autoři: Mihaylova, Anita, Zlatanova, Hristina, Doncheva, Nina, Delev, Delian, Kostadinov, Ilia
Médium: Artigo
Jazyk:Inglês
Vydáno: Mashhad University of Medical Sciences 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570742/
https://ncbi.nlm.nih.gov/pubmed/31231499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2019.33025.7890
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