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Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies
AIMS: To use pharmacostatistical models to characterize tolcapone's pharmacokinetics in parkinsonian patients, and to identify any demographic subpopulations which may be at risk of either under- or over-exposure to this catechol-O-methyltransferase (COMT) inhibitor. METHODS: Four hundred and t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014884/ https://ncbi.nlm.nih.gov/pubmed/10606836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00113.x |
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