A PMLRARα transgene initiates murine acute promyelocytic leukemia

The malignant cells of acute promyelocytic leukemia (APL) contain a reciprocal chromosomal translocation that fuses the promyelocytic leukemia gene (PML) with the retinoic acid receptor α gene (RARα). To test the hypothesis that the chimera PMLRARα plays a role in leukemogenesis, we expressed a PMLR...

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Autores principales: Brown, Diane, Kogan, Scott, Lagasse, Eric, Weissman, Irving, Alcalay, Myriam, Pelicci, Pier Giuseppe, Atwater, Susan, Bishop, J. Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC20126/
https://ncbi.nlm.nih.gov/pubmed/9122233
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