Retinoic acid (RA) and As(2)O(3) treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARα gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes) in t(15;17) or t(11;17), respectively. APL in patients harboring t(15;17) responds well to retinoic a...

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Autors principals: Rego, Eduardo M., He, Li-Zhen, Warrell, Raymond P., Wang, Zhu-Gang, Pandolfi, Pier Paolo
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC27786/
https://ncbi.nlm.nih.gov/pubmed/10954752
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