Retinoic acid (RA) and As(2)O(3) treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARα gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes) in t(15;17) or t(11;17), respectively. APL in patients harboring t(15;17) responds well to retinoic a...

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Detalhes bibliográficos
Main Authors: Rego, Eduardo M., He, Li-Zhen, Warrell, Raymond P., Wang, Zhu-Gang, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27786/
https://ncbi.nlm.nih.gov/pubmed/10954752
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