Retinoic acid (RA) and As(2)O(3) treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARα and PLZF-RARα oncoproteins

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARα gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes) in t(15;17) or t(11;17), respectively. APL in patients harboring t(15;17) responds well to retinoic a...

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Detaylı Bibliyografya
Asıl Yazarlar: Rego, Eduardo M., He, Li-Zhen, Warrell, Raymond P., Wang, Zhu-Gang, Pandolfi, Pier Paolo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2000
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC27786/
https://ncbi.nlm.nih.gov/pubmed/10954752
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