Cancer gene therapy using a survivin mutant adenovirus

We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable Thr(34)→Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability in vitro and in vivo. Infection with pAd-T34A caused spontaneous apoptosis in cell lines of breast, cervical, prostat...

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書目詳細資料

發表在:	J Clin Invest
Principais autores:	Mesri, Mehdi, Wall, Nathan R., Li, Jia, Kim, Richard W., Altieri, Dario C.
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical Investigation 2001
主題:	Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11581299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12983
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