Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

The Ca(2+)-calmodulin-activated Ser/Thr protein phosphatase calcineurin and the downstream transcriptional effectors of calcineurin, nuclear factor of activated T cells, have been implicated in the hypertrophic response of the myocardium. Recently, the calcineurin inhibitory agents cyclosporine A an...

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Detalhes bibliográficos
Main Authors: De Windt, Leon J., Lim, Hae W., Bueno, Orlando F., Liang, Qiangrong, Delling, Ulrike, Braz, Julian C., Glascock, Betty J., Kimball, Thomas F., del Monte, Federica, Hajjar, Roger J., Molkentin, Jeffery D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30652/
https://ncbi.nlm.nih.gov/pubmed/11248077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.031371998
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