Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

The Ca(2+)-calmodulin-activated Ser/Thr protein phosphatase calcineurin and the downstream transcriptional effectors of calcineurin, nuclear factor of activated T cells, have been implicated in the hypertrophic response of the myocardium. Recently, the calcineurin inhibitory agents cyclosporine A an...

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Bibliografische gegevens
Hoofdauteurs: De Windt, Leon J., Lim, Hae W., Bueno, Orlando F., Liang, Qiangrong, Delling, Ulrike, Braz, Julian C., Glascock, Betty J., Kimball, Thomas F., del Monte, Federica, Hajjar, Roger J., Molkentin, Jeffery D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2001
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC30652/
https://ncbi.nlm.nih.gov/pubmed/11248077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.031371998
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