Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

The Ca(2+)-calmodulin-activated Ser/Thr protein phosphatase calcineurin and the downstream transcriptional effectors of calcineurin, nuclear factor of activated T cells, have been implicated in the hypertrophic response of the myocardium. Recently, the calcineurin inhibitory agents cyclosporine A an...

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Autors principals: De Windt, Leon J., Lim, Hae W., Bueno, Orlando F., Liang, Qiangrong, Delling, Ulrike, Braz, Julian C., Glascock, Betty J., Kimball, Thomas F., del Monte, Federica, Hajjar, Roger J., Molkentin, Jeffery D.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC30652/
https://ncbi.nlm.nih.gov/pubmed/11248077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.031371998
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