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Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases

Inhibition of angiogenesis has been shown to be an effective strategy in cancer therapy in mice. However, its widespread application has been hampered by difficulties in the large-scale production of the antiangiogenic proteins. This limitation may be resolved by in vivo delivery and expression of t...

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Main Authors: Sauter, Bernhard V., Martinet, Olivier, Zhang, Wei-Jian, Mandeli, John, Woo, Savio L. C.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18313/
https://ncbi.nlm.nih.gov/pubmed/10758166
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