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Cancer gene therapy using a survivin mutant adenovirus
We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable Thr(34)→Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability in vitro and in vivo. Infection with pAd-T34A caused spontaneous apoptosis in cell lines of breast, cervical, prostat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC200953/ https://ncbi.nlm.nih.gov/pubmed/11581299 |
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