Cancer gene therapy using a survivin mutant adenovirus
We have constructed a replication-deficient adenovirus encoding a nonphosphorylatable Thr(34)→Ala mutant of the apoptosis inhibitor survivin (pAd-T34A) to target tumor cell viability in vitro and in vivo. Infection with pAd-T34A caused spontaneous apoptosis in cell lines of breast, cervical, prostat...
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| 出版年: | J Clin Invest |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11581299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12983 |
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