COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform

Efficient formation of scrapie isoform of prion protein (PrP(Sc)) requires targeting PrP(Sc) by glycophosphatidyl inositol (GPI) anchors to caveolae-like domains (CLDs). Redirecting the cellular isoform of prion protein (PrP(C)) to clathrin-coated pits by creating chimeric PrP molecules with four di...

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Bibliographische Detailangaben
Hauptverfasser: Kaneko, Kiyotoshi, Vey, Martin, Scott, Michael, Pilkuhn, Susanne, Cohen, Fred E., Prusiner, Stanley B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20088/
https://ncbi.nlm.nih.gov/pubmed/9122195
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