COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform

Efficient formation of scrapie isoform of prion protein (PrP(Sc)) requires targeting PrP(Sc) by glycophosphatidyl inositol (GPI) anchors to caveolae-like domains (CLDs). Redirecting the cellular isoform of prion protein (PrP(C)) to clathrin-coated pits by creating chimeric PrP molecules with four di...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Kaneko, Kiyotoshi, Vey, Martin, Scott, Michael, Pilkuhn, Susanne, Cohen, Fred E., Prusiner, Stanley B.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20088/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122195/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2333
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